|
KMID : 1188320160100060902
|
|
Gut and Liver
2016 Volume.10 No. 6 p.902 ~ p.909
|
|
|
Helicobacter pylori Infection with Atrophic Gastritis Is an Independent Risk Factor for Advanced Colonic Neoplasm
|
|
Lee Ji-Young
Park Hye-Won
Choi Ji-Young
Lee Jong-Soo
Koo Ja-Eun
Chung Eun-Ju
Chang Hye-Sook
Choe Jae-Won
Yang Dong-Hoon
Myung Seung-Jae
Jung Hwoon-Yong
Yang Suk-Kyun
Byeon Jeong-Sik
|
|
|
Abstract
|
|
|
Background/Aims: Helicobacter pylori is a major risk factor for atrophic gastritis (AG) and gastric cancer. The correlation between H. pylori, AG and colorectal neoplasm (CRN) has only been examined in a limited number of studies, and findings have been inconclusive. We aimed to investigate the association between H. pylori infection status, AG and advanced CRN.
Methods: This cross-sectional study investigated the relationship between the presence of serum anti-H. pylori IgG antibodies, AG, and advanced CRN in 6,351 consecutive asymptomatic subjects who underwent a screening colonoscopy.
Results: A total of 316 participants (5.0%) had advanced CRN. H. pylori seropositivity was 61.3%. In a univariate analysis, the presence of H. pylori infection was associated with advanced CRN (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.17 to 1.91; p=0.001). H. pylori infection was associated with an increased risk of advanced CRN after adjusting for clinically relevant confounders (OR, 1.34; 95% CI, 1.04 to 1.72; p=0.023). H. pylori-related AG was significantly associated with the risk of advanced CRN (OR, 1.40; 95% CI, 1.03 to 1.91; p=0.030), whereas H. pylori infection without AG was not.
Conclusions: H. pylori infection increased the risk of advanced CRN, especially when it was combined with AG. Strict colonoscopy screening and surveillance may be warranted in those with H. pylori-positive AG.
|
|
|
KEYWORD
|
|
|
Helicobacter pylori, Gastritis, Atrophy, Neoplasms
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|